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Monographs Programme. Because the scope of Volume is so broad, its Monographs are focused on key information. Each Monograph presents a description of a carcinogenic agent and how people are exposed, critical overviews of the epidemiological studies and animal cancer bioassays, and a concise review of the agent's toxicokinetics, plausible mechanisms of carcinogenesis, and potentially susceptible populations, and life-stages.

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How does estrogen, ERT and HRT work Estrogens work by crossing the cell membrane into the cell and attaching to estrogen receptors on the nucleus of the cell. Each type of estrogen has a different ability to attach itself receptor affinity and to stay attached to the receptor on the nucleus nuclear retention. The stronger the receptor affinity, and longer the nuclear retention time, the more potent the physiological action of the estrogen.

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Current or recent past users of hormonal replacement therapy HRT have a higher risk of being diagnosed with breast cancer. Before the link between HRT use and breast cancer risk was established, many postmenopausal women took HRT for many years to ease menopausal symptoms hot flashes, fatigue and to reduce bone loss. Still, many women continue to use HRT to handle bothersome menopausal symptoms.

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How does estrogen function in the body? What are the effects of lower estrogen levels? Estrogen refers both to natural estrogen hormones in the body and estrogen products used in medications.

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For full functionality, it is necessary to enable JavaScript. Here are instructions how to enable JavaScript in your web browser. Healthline Media, Inc.

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For decades, women have used hormone therapy to ease symptoms of menopause, such as hot flashes and sweating. But well-conducted studies have led many doctors to conclude that the risks of MHT often outweigh the benefits. It does not discuss other possible risks of MHT such as heart disease or stroke.

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The size of breast tissue in men and non-lactating women is determined by the amount of adipose fat and connective tissue. Mammary glands develop at the onset of puberty in girls and during pregnancy, produces milk as a food source for a developing child. Each gland comprises a highly branched lactiferous duct system that radiates from the nipple.

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Estrogen replacement therapy ERT was primarily used to treat vasomotor symptoms, and it was increasingly viewed as a way to prevent chronic diseases of aging, including coronary heart disease CHD and cognitive impairment. Findings from these trials have been extensively published during the past decades. Manson et al.

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Estrogen Replacement Therapy ERT is therapy to replace estrogen no longer made by a woman's body because she is post-menopausal or her ovaries have been damaged or removed. For many women, the amount of estrogen produced by the ovaries decreases around the ages of 45 and This decline, which is not noticed by most women, goes on for several years.

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Richard J. Two recent studies have suggested that progestins substantially increase the relative risk RR of breast cancer when added to estrogens as hormone replacement therapy HRT 12 see Figs. If correct, this information could substantially change clinical practice.


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